Gene editing,became more powerful,Gene editing just became even more powerful

Gene editing just became even more powerful

Gene editing just became even more powerful

Gene editing just became even more powerful, Washington Scientists are altering a powerful gene-editing technology in hopes of one day fighting diseases without making permanent changes to people’s DNA.

The trick: Edit RNA instead, the messenger that carries a gene’s instructions.Gene editing,became more powerful,Gene editing just became even more powerful

“If you edit RNA, you can have a reversible therapy,” important in case of side effects, said Feng Zhang of the Broad Institute of MIT and Harvard, a gene-editing pioneer whose team reported the new twist Wednesday in the journal Science.

A genome-editing technique called CRISPR has revolutionized scientific research. It’s a biological cut-and-paste tool that lets researchers spot a gene defect inside living cells and use molecular “scissors” to snip that spot, either deleting, repairing or replacing the affected gene.

Researchers are using CRISPR to try to improve crops, develop malaria-resistant mosquitoes, grow transplantable organs inside animals and develop treatments that one day may help genetic diseases such as sickle cell or muscular dystrophy.

There are challenges for medical use. Because a change to DNA is permanent, accidentally cutting the wrong spot could lead to lasting side effects.

And DNA repair is harder to achieve in certain cells, such as brain and muscle cells, than in others, such as blood cells — so targeting RNA may offer an important alternative, said University of California, San Diego, professor Gene Yeo, who wasn’t involved in Wednesday’s study. His team is creating its own RNA-targeting version of CRISPR.

Disease can occur when a genetic defect leaves cells making too little or too much of a particular protein, or not making it at all.

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 Science  & Technology

 

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